Ibn Sina Journal of Medical Science, Health & Pharmacy

Abstract

The current study aimed to understand the effects of fructose sugar on experimental animals and its impact on blood sugar levels, insulin hormone, insulin sensitivity, as well as its effect on inflammatory proteins including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and signal transducer and activator of transcription 3 (STAT3). Additionally, the study sought to investigate the role of rosemary plant extract. This study was conducted on 15 male rats with an average weight of 180-230 grams and ages of 4-5 months, which were divided into three groups of 5 animals each This study was conducted on 15 male rats with an average weight of 180-230 grams and aged 4-5 months. They were divided into three groups, with 5 rats in each group:
•   Group 1: Considered the control group and given water and regular feed.
•   Group 2: Treated with 2 g/kg of fructose.
•   Group 3: Treated with 2 g/kg of fructose and 50 ml of aqueous rosemary extract.
All groups were orally administered their respective treatments for 30 days.
The results showed a significant increase in sugar levels, insulin, insulin resistance, and inflammatory proteins (TNF-α, IL-6, and STAT3) in the fructose-treated group compared to the control group. In contrast, the group treated with fructose and rosemary extract exhibited a significant reduction in sugar levels, insulin, insulin resistance, and inflammatory proteins. This decrease is attributed to the role of rosemary in mitigating the effects of fructose .
Rosemary might be beneficial in reducing blood sugar levels, enhancing insulin secretion, protecting pancreatic beta cells, and demonstrating inhibitory effects on IL-6, TNF-α, and STAT3.

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Article history_en

Received : Feb 09, 2025

Revised : Feb 12, 2025

Accepted : Apr 22, 2025

Authors Affiliations_en

Wael Issa , AbdAlrahman Masudb

Ethics declarations_en

Acknowledgment	None
Author Contribution	All authors contributed equally to the main contributor to this paper. All authors read and approved the final paper.
Conflicts of Interest	“The authors declare no conflict of interest.”
Funding	“This research received no external funding”