Review Article | Volume 1 Issue 1 (2025) | Published in 2025-06-14
The effect of ACTIVIN A hormone levels in women who suffer from recurrent miscarriages with polycystic ovary syndrome
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Abstract
Introduction: During pregnancy, the placenta is the primary source of the gonadal protein ACTIVIN A in the mother's bloodstream. From mid-pregnancy until close to term, the mother's blood levels of ACTIVIN A rise. Placental malfunction complicates pregnancies, as evidenced by intrauterine foetal growth restriction and significantly higher levels of ACTIVIN A in the mother's blood compared to a normal pregnancy. Experts believe that the elevated blood levels of ACTIVIN A stem from heightened placental synthesis.
OBJECTIVE: This study aimed to determine the levels of the ACTIVIN A hormone in the blood of women with PCOS who experience recurrent miscarriages, compare those levels to those of the control group, and confirm the association between the hormone and maternal age and obesity.
Method: We included ninety women between the ages of fifteen and forty-five in a case-control study; fifty of them had a diagnosis of polycystic ovarian syndrome, while the remaining forty belonged to the healthy control group. The USA-based BioTek Company collected samples between October 2021 and March 2022, using its absorbance ELISA microplate reader and ELISA microplate washer to assess the samples' levels of ACTIVIN A. We calculated the concentration of ACTIVIN A by dividing the weight by the height in square meters.
RESULTS: When compared to the control group, the sick women's levels of ACTIVIN A considerably decreased (P = 0.05). Furthermore, compared to polycystic ovary syndrome patients, the control group had the highest level of AVTIVIN. The concentration was measured based on the body mass index.
CONCLUSION: Patients with polycystic ovarian syndrome had lower levels of ACTIVIN A. Obese women formed a greater percentage of the patients' BMI. Researchers discovered a high amount of ACTIVIN A in the first month of pregnancy. Furthermore, research has linked this hormone to an increase in the frequency of recurrent miscarriages, with the hormone concentration being higher on the day of the most recent miscarriage, which occurs between one and four months, than it is over the longest period of time.
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10.3390/ani15040592